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Registro Completo |
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Biblioteca(s): |
Embrapa Cerrados. |
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Data corrente: |
04/02/2010 |
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Data da última atualização: |
04/02/2010 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SARDINA, M. T.; ROSA, A. J. de M.; BRAGLIA, S.; SCOTTI, E.; PORTOLANO, B. |
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Afiliação: |
MARIA TERESA SARDINA, UNIVERSITÁ DI PALERMO; ARTUR JORDÃO DE MAGALHÃES ROSA, CPAC; SILVIA BRAGLIA, UNIVERSITÁ DI BOLOGNA; EMILIO SCOTTI, UNIVERSITÁ DI BOLOGNA; BALDASSARE PORTOLANO, UNIVERSITÁ DI PALERMO. |
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Título: |
Identification of SNPs in the promoter of ?-lactoglobulin gene in three Sicilian goat breeds. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
Italian Journal of Animal Science, v. 8 (Suplemento 2), p. 147-149, 2009. |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this work was to sequence the full-lenght promoter region of the caprine ?-lactoglobulin (?-lg) gene in three Sicilian goat breeds (Girgentana, Maltese and Derivata do Siria), in order to identify polymorphisms, to search for transcription factors (TFs) sites, and to check if polymorphisms found lay within TFs binding sites. The promoter region of ?-lg gene in Sicilian goat breeds showed high level of polymorphism due to the presence of 31 SNPs. Binding sites for several TFs werw found within the goat ?-lg promoter and within the goat ?-lg promoter and within regions conserved between ovine and caprine species. Two SNPs were detected within TFs binding sites, such as MPBF and NF-1. Further studies are in progress to confirm polymophic sites, to evaluate the possible effect of these mutations on binding affinity of TFs, their relationship with ?-lg gene expression, and functional role of SNPs within the TFs sites of the promoter region on milk traits. |
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Palavras-Chave: |
Beta-Lactoglobulina; SNPs. |
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Thesagro: |
Cabra; Caprino. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01588naa a2200217 a 4500
001 1656692
005 2010-02-04
008 2009 bl --- 0-- u #d
100 1 $aSARDINA, M. T.
245 $aIdentification of SNPs in the promoter of ?-lactoglobulin gene in three Sicilian goat breeds.
260 $c2009
520 $aThe aim of this work was to sequence the full-lenght promoter region of the caprine ?-lactoglobulin (?-lg) gene in three Sicilian goat breeds (Girgentana, Maltese and Derivata do Siria), in order to identify polymorphisms, to search for transcription factors (TFs) sites, and to check if polymorphisms found lay within TFs binding sites. The promoter region of ?-lg gene in Sicilian goat breeds showed high level of polymorphism due to the presence of 31 SNPs. Binding sites for several TFs werw found within the goat ?-lg promoter and within the goat ?-lg promoter and within regions conserved between ovine and caprine species. Two SNPs were detected within TFs binding sites, such as MPBF and NF-1. Further studies are in progress to confirm polymophic sites, to evaluate the possible effect of these mutations on binding affinity of TFs, their relationship with ?-lg gene expression, and functional role of SNPs within the TFs sites of the promoter region on milk traits.
650 $aCabra
650 $aCaprino
653 $aBeta-Lactoglobulina
653 $aSNPs
700 1 $aROSA, A. J. de M.
700 1 $aBRAGLIA, S.
700 1 $aSCOTTI, E.
700 1 $aPORTOLANO, B.
773 $tItalian Journal of Animal Science$gv. 8 (Suplemento 2), p. 147-149, 2009.
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Registro original: |
Embrapa Cerrados (CPAC) |
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